Ran into an application (circa 2001) designed to run on Windows XP. Got it working under Windows 10 after making several changes. First, set the target installation folder to c:\Program Files instead of C:\Program Files (x86). Second, edited the Windows registry to appropriate UNC paths referencing data locations on the server. Afterwards the application and data file(s) loaded successfully.
Note: this is an example where little used techniques worked to allow a modern operating system (Windows 10) to soldier on as the customer's vertical market software solution.